Breakthrough

We are seeking a Principal Technologist – Digital Transformation Strategy to serve as a senior technical leader within the Office of the CTO, partnering with senior business leadership to help shape and advance major digital transformation efforts.   The role will help shape visions into pragmatic, scalable architecture, platforms, and operating capabilities across clinical and operational domains. 

Reporting to the CTO, this role works across business, clinical, operational, and technology leaders to translate priorities into practical technical direction, enabling delivery.   You will act as a trusted advisor on significant technology choices, helping leaders assess options, challenge assumptions, evaluate vendor and partner proposals, and make sound tradeoffs with an eye toward scalability, interoperability, long-term agility, and total cost of ownership. 

This role also helps connect emerging technology opportunities to enterprise reality. You will work with teams across Mayo Clinic and key enterprise partners to guide pilots, inform build-buy-partner decisions, and help promising ideas move from experimentation toward broader impact. 

The ideal candidate brings broad technical credibility, strong judgment, and the ability to communicate clearly with both senior leaders and technical teams. You should be comfortable operating in a matrixed environment, influencing without direct authority, and providing practical guidance in complex, fast-moving situations. This role is designed to complement existing architecture, infrastructure, and digital engineering functions rather than duplicate operational ownership.

•    Includes optional responsibility for leading or coaching advanced technical teams (e.g., AI builders, innovation teams) - thinking just in case we would ever want to try a pod of engineers or some other role reporting to this person 
•    Validate that enterprise principles, reference architectures, and roadmaps are accurately and consistently applied. 
•    Continuously scan external market, partner ecosystem, and emerging technology landscape to inform strategy and partnerships 
•    Help us define structured pathways for scaling pilots (AI/ML, robotics, digital twin, edge, etc.) from experimentation to enterprise/campus-wide impact 
•    Serve as a data-driven “technical truth teller”, challenging assumptions and protecting long-term agility and total cost of ownership. Especially when evaluating vendor proposals and technical architectures. 
•    Ensure platform-first thinking across all technical decisions, leveraging enterprise platforms (e.g., Mayo Clinic Platform) wherever possible 
•    Potentially could lead RFI/RFP technical criteria definition and evaluation processes, including structured scoring and benchmarking

Required Skills:

Strategic technical leadership. Able to translate business priorities into practical technical direction across architecture, platforms, and operating capabilities, while keeping an enterprise view of scale, interoperability, resilience, and long-term fit. This aligns with the Principal Technologist expectation to guide technology strategy, maintain a multi-year outlook, and connect business strategy to technology investments.   

Enterprise architecture and systems thinking. Sees across domains rather than within a single tower. Understands how application, data, infrastructure, integration, and platform choices interact, and can evaluate implications beyond the immediate project. The underlying role also emphasizes advanced expertise across multiple technologies and pragmatic architectural leadership.     

Technical judgment and decision quality. Strong at assessing options, pressure-testing assumptions, evaluating vendor proposals, and guiding build-buy-partner decisions. Comfortable making defensible tradeoffs under ambiguity and helping leaders avoid short-term choices that create long-term drag. 

Innovation evaluation and scaling. Able to assess emerging technologies realistically, guide pilots, and determine what can move from experimentation to enterprise impact. This fits the Principal Technologist’s role in monitoring industry direction, vendor landscape, and future-state technology fit.   

Executive communication and translation. Can explain complex technical issues in plain language, communicate clearly with senior business leaders, and also maintain credibility with architects and engineers. That translation ability is explicitly central to the base role.     

Influence in a matrixed environment. Builds alignment without relying on direct authority. Works effectively across business, clinical, operational, and technical stakeholders, and complements existing functions instead of creating overlap. The original Principal Technologist role likewise emphasizes partnership, change leadership, and broad influence.     

This is full time, hybrid position with expectations of 1 day working on campus per week.  The incumbent must live within 100 miles of the Jacksonville, FL campus.  Mayo Clinic will not sponsor or transfer visas for this position including F1 OPT STEM.

Bachelor's degree in information technology or related technical field plus ten years of progressive technology leadership experience required; Or, Associate's degree in information technology or related technical field plus 12 years of progressive technology leadership experience. Administrative experience must include working with corporate leadership, administrators and technology staff with demonstrated ability to partner with senior leadership. Exceptional technical acumen, business acumen and ability to simplify and communicate complex topics in business language. Experience in information technology architecture, software product development and acquisition, development and management of database systems, infrastructure and operations for data networks and computer hardware acquisition and deployment. Excellent communication and team building and collaboration skills. Demonstrated ability to develop architectural designs and provide pragmatic and effective leadership for their development and implementation.

Experience working in or with Healthcare Industry. Advanced expertise in multiple technologies. Experience or qualification in related fields, such as medical informatics, statistics, or engineering. Advanced project and deliverable consistency through repeatable and reliable performance. Advanced initiative and self-motivation to complete tasks and assignments on time. Experience working with healthcare technology. Must be able to work independently and able to lead and mentor in a team environment. Masters degree in applicable field preferred.